How it works.
ACE-031 (ramatercept) is a dimeric fusion of the extracellular domain of the activin receptor type IIB (ActRIIB) and the Fc region of human IgG1. It functions as a decoy receptor, binding myostatin (GDF-8), activin A, and GDF-11 in circulation before they can engage endogenous ActRIIB. Sequestering these negative regulators relieves their suppression of muscle growth; in animal research the result is increased muscle mass and effects on bone density.
Verified buyer notes.
Initials only — every quote is verified against an order record. We don’t ghost-write reviews.
“COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.”
“Switched after two bad lots from a previous source. Three orders in, zero issues.”
“Shipment got delayed two days by weather and still arrived at 4°C. Packaging is no joke.”
The shared signature.
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