How it works
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide derived from the sequence of epithalamin, a peptide complex isolated from the pineal gland. In published research it is associated with induction of telomerase activity in somatic cell cultures — extending replicative capacity — alongside effects on melatonin regulation and circadian rhythm. It is studied primarily in the context of aging biology and pineal-gland signaling in cell and animal models.
Learn more about the science →Certificate of Analysis+
LC-MS identity, HPLC purity (≥99%), mass spec confirmation, endotoxin by LAL, appearance. Third-party ISO-17025 verified.
View full certificate →Specifications+
Storage & handling+
Lyophilized: −20°C, 24 months. Reconstituted: 2–8°C, use within 30 days. Reconstitute with bacteriostatic water; swirl gently, protect from light.
We ship in insulated parcels with phase-change cooling and a tamper-evident seal.
FAQs+
What is Epithalon derived from?+
It is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a peptide complex isolated from the pineal gland. The synthetic version replicates the active sequence.
Why is Epithalon in Longevity Research?+
Longevity Research collects compounds studied for systemic vitality and aging-related work. Epithalon's pineal and telomerase research context sits there.
What pathway is most associated with Epithalon?+
Telomerase induction in cell-culture research, plus effects on melatonin and circadian regulation attributed to its pineal-peptide origin.
What's a typical reconstitution concentration?+
Investigator-dependent. A common preparation is 2 mL bacteriostatic water per 10mg vial, yielding 5 mg/mL.
How is Epithalon quality verified?+
LC-MS identity and HPLC purity per lot, mass spec against the theoretical mass, and a third-party ISO-17025 repeat assay.
Is Epithalon subscription-eligible?+
Yes. 15% off on a 60-day cycle once it returns to stock.
The research behind this compound, cited in full.
Provided for context only. None of the studies cited below evaluate hábit material specifically; they document the published literature on the compound and its mechanism. Research-use claims are not therapeutic claims.
- [01] Khavinson VK. et al. Bull Exp Biol Med 132 (2001): 1080–1083.
- [02] Anisimov VN. et al. Mech Ageing Dev 122 (2001): 41–68.
- [03] Khavinson VK. & Morozov VG. Neuro Endocrinol Lett 24 (2003): 233–240.
- [04] Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties
Verified buyer notes
Initials only — every quote is verified against an order record. We don’t ghost-write reviews.
“COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.”
“Switched after two bad lots from a previous source. Three orders in, zero issues.”
“Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.”