How it works
Glutathione (GSH) is a tripeptide of glutamate, cysteine, and glycine, distinguished by an unusual γ-carboxyl peptide bond that resists standard peptidases. It is the most abundant intracellular thiol antioxidant. The reactive cysteine thiol neutralizes reactive oxygen species and, via glutathione peroxidase, reduces peroxides; the resulting oxidized dimer (GSSG) is recycled by glutathione reductase using NADPH. GSH is also central to phase-II detoxification through glutathione-S-transferase conjugation. Cellular GSH:GSSG ratio is a widely used index of redox status in research.
Learn more about the science →Certificate of Analysis+
Identity by HPLC and thiol assay, purity by HPLC (≥99%), endotoxin by LAL, residual solvent screening, appearance. Third-party ISO-17025 verified.
View full certificate →Specifications+
Storage & handling+
Lyophilized: −20°C, 24 months. Reconstituted: 2–8°C, use within 14 days — reduced glutathione oxidizes readily in solution. Reconstitute with sterile water; minimize air exposure and protect from light.
We ship in insulated parcels with phase-change cooling and a tamper-evident seal.
FAQs+
Why is glutathione in Dermal Research?+
Dermal Research collects compounds studied in skin and connective-tissue contexts. Alongside its systemic redox role, glutathione is studied for tyrosinase inhibition and melanogenesis, which places it here next to GHK-Cu.
Why does reduced glutathione have a short solution window?+
The reactive cysteine thiol that makes GSH an antioxidant also oxidizes readily to GSSG in air. Cold storage, minimal air exposure, and a 14-day window preserve the reduced form.
How is glutathione different from NAD+?+
Both are cellular cofactors, but distinct systems: NAD+ drives redox reactions and sirtuin signaling; glutathione is the primary thiol antioxidant and detoxification substrate. NADPH regenerates reduced glutathione, so the two systems are linked.
What's a typical reconstitution concentration?+
Investigator-dependent. A common preparation is 3 mL sterile water per 600mg vial, yielding 200 mg/mL.
How is the reduced form verified?+
A free-thiol assay confirms GSH content alongside HPLC identity and purity, with a third-party ISO-17025 repeat assay.
Is glutathione subscription-eligible?+
Yes. 15% off on a 60-day cycle once it returns to stock.
The research behind this compound, cited in full.
Provided for context only. None of the studies cited below evaluate hábit material specifically; they document the published literature on the compound and its mechanism. Research-use claims are not therapeutic claims.
- [01] Meister A. & Anderson ME. Annu Rev Biochem 52 (1983): 711–760.
- [02] Forman HJ. et al. Mol Aspects Med 30 (2009): 1–12.
- [03] Wu G. et al. J Nutr 134 (2004): 489–492.
- [04] Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
Verified buyer notes
Initials only — every quote is verified against an order record. We don’t ghost-write reviews.
“COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.”
“Switched after two bad lots from a previous source. Three orders in, zero issues.”
“Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.”