How it works
KPV is the C-terminal tripeptide (lysine-proline-valine) of α-melanocyte-stimulating hormone. It retains the anti-inflammatory activity of the parent hormone while lacking its melanocortin-receptor pigmentation effects. Published research suggests KPV acts intracellularly — entering cells partly via the PepT1 transporter — to inhibit pro-inflammatory signaling cascades such as NF-κB and downstream cytokine production. It is studied in models of colitis, wound healing, and mucosal repair for effects on inflammation and tissue recovery.
Learn more about the science →Certificate of Analysis+
LC-MS identity, HPLC purity (≥99%), mass spec confirmation, endotoxin by LAL, appearance. Third-party ISO-17025 verified.
View full certificate →Specifications+
Storage & handling+
Lyophilized: −20°C, 24 months. Reconstituted: 2–8°C, use within 30 days. Reconstitute with bacteriostatic water; swirl gently, protect from light.
We ship in insulated parcels with phase-change cooling and a tamper-evident seal.
FAQs+
What is KPV derived from?+
It is the C-terminal tripeptide (Lys-Pro-Val) of α-MSH. It keeps the parent hormone's anti-inflammatory activity but not its melanocortin-receptor pigmentation effects.
Why is KPV in Longevity Research?+
Longevity Research covers broad-spectrum compounds studied for systemic effects. KPV is the C-terminal tripeptide of α-MSH, and its anti-inflammatory and mucosal-healing research context runs across tissues rather than sitting within one system.
How is KPV thought to act?+
Research suggests an intracellular anti-inflammatory mechanism — uptake partly via the PepT1 transporter and inhibition of NF-κB signaling — rather than a classical melanocortin-receptor route.
What's a typical reconstitution concentration?+
Investigator-dependent. A common preparation is 2 mL bacteriostatic water per 10mg vial, yielding 5 mg/mL.
How is KPV quality verified?+
LC-MS identity and HPLC purity per lot, mass spec against the theoretical mass, and a third-party ISO-17025 repeat assay.
Is KPV subscription-eligible?+
Yes. 15% off on a 60-day cycle once it returns to stock.
The research behind this compound, cited in full.
Provided for context only. None of the studies cited below evaluate hábit material specifically; they document the published literature on the compound and its mechanism. Research-use claims are not therapeutic claims.
- [01] Luger TA. & Brzoska T. Ann Rheum Dis 66 (2007): iii52–iii55.
- [02] Kannengiesser K. et al. Inflamm Bowel Dis 14 (2008): 324–331.
- [03] Dalmasso G. et al. Gastroenterology 134 (2008): 166–178.
- [04] PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation
Verified buyer notes
Initials only — every quote is verified against an order record. We don’t ghost-write reviews.
“COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.”
“Switched after two bad lots from a previous source. Three orders in, zero issues.”
“Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.”