How it works.
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is one of a small family of mitochondrial-derived peptides. Under metabolic stress it translocates from the mitochondria to the nucleus, where published research has documented effects on AMPK-pathway activation and the folate–methionine one-carbon cycle. It is studied as a regulator of metabolic homeostasis, insulin sensitivity, and exercise-associated adaptation in cell and animal models.
12S rRNA ORF→16-aa peptide
Metabolic stress→nuclear translocation
AMPK pathway→metabolic homeostasis
From researchers using MOTS-c
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Other cofactors in neural and mitochondrial work.
