How it works
Pinealon is a three-residue peptide (Glu-Asp-Arg) from the Khavinson bioregulator series. The proposed mechanism is unusual for a peptide of this size: short peptides in this class are reported to enter the nucleus and interact directly with DNA, modulating transcription rather than acting through a surface receptor. Published work examines neuronal survival under oxidative and hypoxic stress in cortical culture. The mechanism remains less established than for receptor-mediated peptides, and the literature is concentrated in a narrower set of groups.
Learn more about the science →Certificate of Analysis+
LC-MS identity, HPLC purity, mass spec confirmation, endotoxin by LAL, appearance. Third-party ISO-17025 verified.
View full certificate →Specifications+
Storage & handling+
Lyophilized: −20°C, protected from light. Reconstituted: 2–8°C. Reconstitute with bacteriostatic water; swirl gently.
We ship in insulated parcels with phase-change cooling and a tamper-evident seal.
FAQs+
What is a peptide bioregulator?+
A class of short peptides — usually two to four residues — proposed to act on transcription directly rather than through a surface receptor. Pinealon and Epithalon both come from that series.
How settled is the mechanism?+
Less settled than for receptor-mediated compounds. The nuclear-interaction model is proposed rather than established, and the literature comes from a comparatively narrow set of groups. Worth knowing when designing around it.
Why is Pinealon in Neuro?+
Its published research context is neuronal viability under oxidative and hypoxic stress in cortical models.
What identity check matters most?+
Mass spec against 434.41 g/mol. At three residues the mass window is tight, so a truncation or a missing residue is unambiguous.
The research behind this compound, cited in full.
Provided for context only. None of the studies cited below evaluate hábit material specifically; they document the published literature on the compound and its mechanism. Research-use claims are not therapeutic claims.
- [01] Khavinson V.K. et al. Bull Exp Biol Med 152 (2011): 288–291.
- [02] Ashapkin V.V. et al. Biogerontology 16 (2015): 235–247.
Verified buyer notes
Initials only — every quote is verified against an order record. We don’t ghost-write reviews.
“COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.”
“Switched after two bad lots from a previous source. Three orders in, zero issues.”
“Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.”