How it works
Semax is a synthetic analog of the ACTH(4-10) fragment, extended at the C-terminus with a Pro-Gly-Pro motif that confers resistance to peptidase cleavage while removing the corticotropic activity of the parent hormone. In published research it is associated with increased expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, modulation of the dopaminergic and serotonergic systems, and neuroprotective effects in models of ischemic and cognitive stress.
Learn more about the science →Certificate of Analysis+
LC-MS identity, HPLC purity (≥99%), mass spec confirmation, endotoxin by LAL, appearance. Third-party ISO-17025 verified.
View full certificate →Specifications+
Storage & handling+
Lyophilized: −20°C, 24 months. Reconstituted: 2–8°C, use within 30 days. Reconstitute with bacteriostatic water or saline; swirl gently, protect from light.
We ship in insulated parcels with phase-change cooling and a tamper-evident seal.
FAQs+
What is Semax derived from?+
It is a synthetic analog of the ACTH(4-10) fragment with an added Pro-Gly-Pro tail. The modification removes corticotropic activity while extending stability.
What pathway is most associated with Semax?+
BDNF/TrkB neurotrophic signaling. Published work also describes effects on the dopaminergic and serotonergic systems and neuroprotection in ischemic models.
Why is Semax in Neurological Research?+
It is a nootropic neuropeptide studied for central nervous-system effects — squarely within Neurological Research's cognition-and-repair scope.
What's a typical reconstitution concentration?+
Investigator-dependent. A common preparation is 2 mL bacteriostatic water per 30mg vial, yielding 15 mg/mL.
How is Semax quality verified?+
LC-MS identity and HPLC purity per lot, mass spec against the theoretical mass, and a third-party ISO-17025 repeat assay.
Is Semax subscription-eligible?+
Yes. 15% off on a 60-day cycle once it returns to stock.
The research behind this compound, cited in full.
Provided for context only. None of the studies cited below evaluate hábit material specifically; they document the published literature on the compound and its mechanism. Research-use claims are not therapeutic claims.
- [01] Dolotov OV. et al. J Neurosci Res 84 (2006): 1443–1451.
- [02] Kaplan AY. & Kochetova AG. Neurosci Behav Physiol 33 (2003): 833–839.
- [03] Shadrina MI. et al. Front Pharmacol 12 (2021): 669601.
- [04] Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in rat brain
Verified buyer notes
Initials only — every quote is verified against an order record. We don’t ghost-write reviews.
“COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.”
“Switched after two bad lots from a previous source. Three orders in, zero issues.”
“Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.”