How it works.

SS-31 (elamipretide) is a synthetic tetrapeptide with an alternating aromatic-cationic motif that lets it cross cell membranes and concentrate several-thousand-fold in the inner mitochondrial membrane. There it associates selectively with cardiolipin, the signature phospholipid of the inner membrane. In published research this interaction is linked to stabilization of cristae architecture, improved electron-transport-chain coupling, and reduced mitochondrial reactive-oxygen-species output in models of age- and stress-related mitochondrial dysfunction.

aromatic-cationic motifinner-membrane targeting
binds cardiolipincristae stabilization
ETC coupling ↑↓ mitochondrial ROS

Verified buyer notes.

Initials only — every quote is verified against an order record. We don’t ghost-write reviews.

COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.
M.O.Boston, MAApril 2026
Switched after two bad lots from a previous source. Three orders in, zero issues.
J.K.Austin, TXMarch 2026
Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.
S.L.Chicago, ILFebruary 2026