How it works
Thymosin beta-4 (Tβ4) is a 43-amino-acid actin-sequestering peptide present in nearly all mammalian cells. TB-500 is a synthetic fragment representing the active region, retaining the actin-binding domain. In published work, the parent compound and TB-500 fragment have been studied for effects on cell migration, angiogenesis, and tissue repair through actin cytoskeletal regulation.
Learn more about the science →Certificate of Analysis+
LC-MS identity, HPLC purity, mass spec, endotoxin, appearance. Third-party ISO-17025 verified.
View full certificate →Specifications+
Storage & handling+
Lyophilized: −20°C, 24 months. Reconstituted: 2–8°C, 30 days. Bacteriostatic water.
We ship in insulated parcels with phase-change cooling and a tamper-evident seal.
FAQs+
Is TB-500 the same as full-length Tβ4?+
No. TB-500 is a synthetic fragment of the active region. Pharmacokinetics and stability differ from full-length Tβ4.
Why is TB-500 often paired with BPC-157?+
Different mechanisms, complementary effects on tissue repair. BPC-157: angiogenesis and fibroblast pathways. TB-500: actin and cell migration.
Is TB-500 stable in solution?+
Yes, with standard cold storage. 30 days at 2–8°C is the operating spec.
What's the typical reconstitution volume?+
Common preparation: 2 mL bacteriostatic water per 10mg vial, yielding 5 mg/mL.
Is TB-500 subscription-eligible?+
Yes. 15% off on a 60-day cycle.
How is TB-500 quality typically compromised?+
Truncation impurities and incorrect acetylation. Mass spec resolves truncations; HPLC purity tracks acetylation. Both documented on every COA.
The research behind this compound, cited in full.
Provided for context only. None of the studies cited below evaluate hábit material specifically; they document the published literature on the compound and its mechanism. Research-use claims are not therapeutic claims.
- [01] Goldstein AL. et al. Ann N Y Acad Sci 1112 (2007): 1–13.
- [02] Sosne G. et al. Exp Eye Res 74 (2002): 293–299.
- [03] Crockford D. et al. Ann N Y Acad Sci 1194 (2010): 179–189.
- [04] Thymosin β4: a multi-functional regenerative peptide
Verified buyer notes
Initials only — every quote is verified against an order record. We don’t ghost-write reviews.
“COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.”
“Switched after two bad lots from a previous source. Three orders in, zero issues.”
“Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.”