How it works
Vasoactive intestinal peptide (VIP) is a 28-residue member of the secretin/glucagon peptide superfamily. It signals through the class-B G-protein-coupled receptors VPAC1 and VPAC2, coupling primarily to adenylate cyclase and cAMP. In published research it is characterized for vasodilatory effects, anti-inflammatory and immunomodulatory activity, roles in the suprachiasmatic-nucleus circadian pacemaker via VPAC2, and neuroprotective signaling. Its broad receptor expression makes it a widely studied endogenous regulatory peptide.
Learn more about the science →Certificate of Analysis+
LC-MS identity, HPLC purity (≥99%), mass spec confirmation, endotoxin by LAL, appearance. Third-party ISO-17025 verified.
View full certificate →Specifications+
Storage & handling+
Lyophilized: −20°C, 24 months. Reconstituted: 2–8°C, use within 14 days — VIP is more labile in solution than smaller peptides. Reconstitute with bacteriostatic water; protect from light, avoid repeated freeze-thaw.
We ship in insulated parcels with phase-change cooling and a tamper-evident seal.
FAQs+
What receptors does VIP act on?+
The class-B GPCRs VPAC1 and VPAC2, signaling largely through cAMP. Receptor distribution is broad, which is why VIP is studied across vascular, immune, and central-nervous-system contexts.
Why is VIP in Longevity Research?+
Longevity Research covers broad-spectrum compounds studied for systemic effects. VIP signals across vascular, immune and circadian pathways rather than sitting within a single system, which places it here.
Why the shorter post-reconstitution window?+
As a larger, methionine-containing peptide, VIP is more labile in solution. A 14-day window at 2–8°C with light protection minimizes potency loss.
What's a typical reconstitution concentration?+
Investigator-dependent. A common preparation is 2 mL bacteriostatic water per 10mg vial, yielding 5 mg/mL.
How is VIP quality verified?+
LC-MS identity and HPLC purity per lot, mass spec against the theoretical mass, and a third-party ISO-17025 repeat assay.
Is VIP subscription-eligible?+
Yes. 15% off on a 60-day cycle once it returns to stock.
The research behind this compound, cited in full.
Provided for context only. None of the studies cited below evaluate hábit material specifically; they document the published literature on the compound and its mechanism. Research-use claims are not therapeutic claims.
- [01] Said SI. & Mutt V. Science 169 (1970): 1217–1218.
- [02] Delgado M. & Ganea D. Amino Acids 45 (2013): 25–39.
- [03] Vaudry D. et al. Pharmacol Rev 61 (2009): 283–357.
- [04] Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes
Verified buyer notes
Initials only — every quote is verified against an order record. We don’t ghost-write reviews.
“COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.”
“Switched after two bad lots from a previous source. Three orders in, zero issues.”
“Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.”