How it works.

Vasoactive intestinal peptide (VIP) is a 28-residue member of the secretin/glucagon peptide superfamily. It signals through the class-B G-protein-coupled receptors VPAC1 and VPAC2, coupling primarily to adenylate cyclase and cAMP. In published research it is characterized for vasodilatory effects, anti-inflammatory and immunomodulatory activity, roles in the suprachiasmatic-nucleus circadian pacemaker via VPAC2, and neuroprotective signaling. Its broad receptor expression makes it a widely studied endogenous regulatory peptide.

VIP (secretin family)VPAC1 · VPAC2 receptors
cAMP signalingvasodilation · immunomodulation
VPAC2 (SCN)circadian regulation

Verified buyer notes.

Initials only — every quote is verified against an order record. We don’t ghost-write reviews.

COA matched what we ran in-house. Powder reconstituted clean, no haze. Did exactly what we needed it to.
M.O.Boston, MAApril 2026
Switched after two bad lots from a previous source. Three orders in, zero issues.
J.K.Austin, TXMarch 2026
Asked support a purity question and got the raw HPLC trace back within the hour. That transparency is why we reorder.
S.L.Chicago, ILFebruary 2026